March15, 2013 : 9.30 a.m. - 3 p.m.

Seminar Room of the Institute of Molecular Genetics ASCR

Part I (9.30 a.m.-12 a.m., each talk will be 30 min including discussion)

Dr. Radek Sedlacek (chair of the session, Institute of Molecular Genetics & BIOCEV, ASCR Prague): "The Czech Centre for Phenogenomics and Functional Genomics in BIOCEV"

Dr. Ralf Kühn (Helmholtz Zentrum, München, Germany): "Direct Production of Mouse Disease Models by Embryo Microinjection of TALENs and Oligodeoxynucleotides"

Dr. John Brognard (Paterson Institute for Cancer Research, The University of Manchester, UK): "Utilising Genetic Dependency Screens to Identify Mutationally Activated Drivers of Lung Cancer"

Dr. Libor Macurek (Institute of Molecular Genetics, ASCR Prague): Role of PPM1D/Wip1 mutations in DNA damage signaling and cancer development

Dr. Meritxell Alberich Jorda (Institute of Molecular Genetics, ASCR Prague): "The interplay between C/EBPa and C/EBPg in acute myeloid leukemia"

Before lunch the organizers will appreciate participation of all sponsors and will point to their exhibition area. Dr. Aleš Merta (Life Technologies Czech Republic s.r.o.) will shortly introduce their NGS and PCR tools: "Ion Torrent – Semiconductor Next Generation Sequencing and Advanced Real-Time PCR Systems, Digital PCR and Open Array Technologies from Life Technologies/Applied Biosystems."

12 a.m. - 1 p.m. time for lunch

Part II (1 p.m.- 3 p.m., each talk will be 30 min including discussion)

Dr. Philipp Greif (Helmholtz Zentrum, München, Germany): "Exome Sequencing Identifies Cooperating Transcription Factor Mutations in Acute Myeloid Leukemia (AML): Simultaneous Targeting of GATA2 and CEBPA"

Dr. Tomas Stopka (chair of the session, Pathophysiology & BIOCEV, First Faculty of Medicine, Charles University in Prague): "Regulation of PU.1 gene transcription in MDS and AML."

Dr. Peter Laslo (Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK): "Epigenetic regulation of the myeloid gene network by the BCR-ABL oncogene"

Dr. John Strouboulis (Institute of Molecular Oncology, BSRC Alexander Fleming, Varkiza, Greece): "GATA-1 regulatory networks in erythroid cells."