1st Faculty of Medicine Charles University 1st Faculty of Medicine Charles University Genes, Genetics & Genomics

G3 Talks dedicated to "NGS in Myeloid Malignancies"

May 30, 2018 at 1PM to be held in the Hematology Clinic, General Hospital, Prague, U nemocnice 2, entrance A12 (lecture will be clinically oriented) and

May 31, 2018 at 10AM in BIOCEV, Vestec, Průmyslová 595, U2.012 (basic science oriented) presenting lecture:

"Computational Modeling of Protein Networks Predicts Treatment Outcomes in Hematological Malignancies"


The myriad of genomic aberrations within tumor cells contributes to disease complexity and affects protein signaling networks imperative for chemosensitivity. We have developed and validated a computational biology modeling (CBM) approach to translate all genomic abnormalities into disease-relevant protein network maps, which can be digitally screened to predict clinical outcomes to 67 FDA-approved drugs. CBM has the potential to predict patient response to therapy, predict novel combinations of drugs with potential therapeutic activity, identify mechanisms of drug sensitivity and resistance, and identify patient-specific biomarkers related to their unique mutanome.


Dr. Leylah Drusbosky  

Research Assistant Professor
Scientific Director
Hematology Oncology
University of Florida